ASTEPRO 0.15%—the Earlier the Better

Proven Efficacy Safe and Well-Tolerated Patient Coverage

Proven Efficacy
Used once-daily, ASTEPRO 0.15% relieves seasonal allergic rhinitis (SAR) symptoms, including nasal congestion—without an added decongestant1,2



  • Results of a 2-week, placebo-controlled, double-blind study that compared ASTEPRO 0.15%, 2 sprays per nostril once daily, with placebo in patients with SAR
  • The primary efficacy variable was the change from baseline in the 12-hour reflective Total Nasal Symptom Score (TNSS) over the entire 2 weeks of treatment
  • TNSS consisted of nasal congestion, itchy nose, runny nose, and sneezing, scored on a 4-point (0–3) scale such that the maximum daily score was 24
  • Change in TNSS from baseline for ASTEPRO 0.15% was -3.3 and -1.9 for placebo (P-value<.001)

  • ASTEPRO 0.15% also provides significant improvements with twice-daily dosing for patients with perennial allergic rhinitis vs placebo (P=.03)1
  • Works in as early as 30 to 45 minutes3,4
    • In 2 placebo-controlled SAR studies (N=1143), ASTEPRO 0.15% (2 sprays per nostril) relieved allergic rhinitis symptoms in as early as 30 to 45 minutes, and the effect remained durable over the 4-hour assessment period

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Safe and Well-Tolerated


Decongestants, such as pseudoephedrine, should be used with caution in older patients and patients with a history of:

  • Hypertension
  • Urinary dysfunction
  • Cardiac arrhythmia
  • Diabetes
  • Hyperthyroidism
  • Glaucoma

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Well-tolerated relief, as shown in clinical trials1

  • Less than 1% of patients reported somnolence
  • Only 4% of patients reported bitter taste with 2 sprays per nostril once daily
  • In clinical studies, the most commonly reported adverse reactions, when dosed at 2 sprays per nostril once or twice daily, respectively, included bitter taste (4%, 6%), nasal discomfort (4%, 3%), epistaxis (2%, 1%), and sneezing (1%, 2%)
  • Less than 2% discontinuation rate

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ASTEPRO 0.15% Has Your Patients Covered


1 Rx 1 copay Nearly 2 months of therapy
  • With the Instant Savings Card, eligible patients pay no more than $25*
  • May minimize callbacks from pharmacies and patients
  • When prescribed once daily for seasonal allergic rhinitis—Calculation based on 2 sprays per nostril once daily
  • May result in fewer copays per year


*For eligible insured patients only. Coupon covers the balance of the copay over $25 (if any) for the first unit dispensed and for refills. Maximum value of $100 per dispensed unit. Offer expires 12/31/2012. Please see full program terms and conditions on the back of the Instant Savings Card brochure or visit ASTEPRO.com.

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Indication

ASTEPRO® (azelastine HCl) Nasal Spray 0.15% is indicated for the relief of the symptoms of seasonal and perennial allergic rhinitis in patients 12 years of age and older.

Important Risk Information

  • Avoid engaging in hazardous occupations requiring complete mental alertness when taking ASTEPRO Nasal Spray 0.15%
  • Avoid concurrent use of alcohol or other central nervous system depressants with ASTEPRO Nasal Spray 0.15%
  • In clinical studies, the most commonly reported adverse reactions, when dosed at 2 sprays per nostril once or twice daily, respectively, included bitter taste (4%, 6%), nasal discomfort (4%, 3%), epistaxis (2%, 1%), and sneezing (1%, 2%)
  • Pregnancy Category C: Based on animal data, may cause fetal harm
    Please see full Prescribing Information
    You are encouraged to report negative side effects of prescription drugs to the FDA.
    Visit www.fda.gov/medwatch, or call 1‐800‐FDA‐1088